Pesquisa | BVS IEC

1.

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.

Burris-Hiday, Sarah D; Scott, Emily E.

J Biol Chem ; 299(9): 105112, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37517692

2.

Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice.

Li, Yang; Kazuki, Yasuhiro; Drabison, Thomas; Kobayashi, Kaoru; Fujita, Ken-Ichi; Xu, Yue; Jin, Yan; Ahmed, Eman; Li, Junan; Eisenmann, Eric D; Baker, Sharyn D; Cavaletti, Guido; Sparreboom, Alex; Hu, Shuiying.

Drug Metab Dispos ; 52(2): 80-85, 2024 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-38071551

3.

Interaction of the antifungal ketoconazole and its diphenylphosphine derivatives with lipid bilayers: Insights into their antifungal action.

Bento-Oliveira, Andreia; Starosta, Radoslaw; de Almeida, Rodrigo F M.

Arch Biochem Biophys ; 753: 109919, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38307316

4.

Tumour induction in BALB/c mice for imaging studies: An improved protocol.

Amini, Abolfazl; Mesbah, Gholamreza; Tash Shamsabadi, Fatemeh; Zeyghami, Mohammad Ali; Safdari, Yaghoub.

J Cell Mol Med ; 27(13): 1880-1886, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37246626

5.

The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells.

Lin, Yiqi Christina; Cheung, Garett; Porter, Edith; Papadopoulos, Vassilios.

J Biol Chem ; 298(7): 102110, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35688208

6.

Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma.

Dimitrijevic, Dunja; Fabian, Eric; Funk-Weyer, Dorothee; Landsiedel, Robert.

Biochem Biophys Res Commun ; 651: 114-120, 2023 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-36812744

7.

Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.

Kamble, Shyam H; Obeng, Samuel; León, Francisco; Restrepo, Luis F; King, Tamara I; Berthold, Erin C; Kanumuri, Siva Rama Raju; Gamez-Jimenez, Lea R; Pallares, Victoria L C; Patel, Avi; Ho, Nicholas P; Hampson, Aidan; McCurdy, Christopher R; McMahon, Lance R; Wilkerson, Jenny L; Sharma, Abhisheak; Hiranita, Takato.

J Pharmacol Exp Ther ; 385(3): 180-192, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-37019472

8.

In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A.

Wang, Aixuan; Zhao, Qiang; Liu, Minglu; Wang, Yang; Zhao, Guode; Li, Weiwei; Peng, Ying; Zheng, Jiang.

Chem Res Toxicol ; 36(3): 479-491, 2023 03 20.

Artigo em Inglês | MEDLINE | ID: mdl-36795936

9.

Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconazole Cocrystal.

Kataoka, Makoto; Yonehara, Ayaka; Minami, Keiko; Takagi, Toshihide; Yamashita, Shinji.

Mol Pharm ; 20(8): 4100-4107, 2023 08 07.

Artigo em Inglês | MEDLINE | ID: mdl-37354097

10.

Integrating Forward and Reverse Translation in PBPK Modeling to Predict Food Effect on Oral Absorption of Weakly Basic Drugs.

Franco, Yesenia L; Da Silva, Lais; Charbe, Nitin; Kinvig, Hannah; Kim, Soyoung; Cristofoletti, Rodrigo.

Pharm Res ; 40(2): 405-418, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36788156

11.

Drug-Polymer Miscibility and the Overlap Concentration (C*) as Measured by Rheology: Variation of Polymer Structure.

Sahoo, Anasuya; Siegel, Ronald A.

Pharm Res ; 40(9): 2229-2237, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37552386

12.

Ketoconazole-loading strategy to improve antifungal activity and overcome cytotoxicity on human renal proximal tubular epithelial cells.

Coksu, Irem; Bozkurt, Yagmur; Akmayan, Ilkgul; Demirci, Hasan; Ozbek, Tulin; Acar, Serap.

Nanotechnology ; 35(11)2023 Dec 27.

Artigo em Inglês | MEDLINE | ID: mdl-38081071

13.

Chemical Imaging of Pharmaceuticals in Biofilms for Wastewater Treatment Using Secondary Ion Mass Spectrometry.

Burzio, Cecilia; Mohammadi, Amir Saeid; Malmberg, Per; Modin, Oskar; Persson, Frank; Wilén, Britt-Marie.

Environ Sci Technol ; 57(19): 7431-7441, 2023 05 16.

Artigo em Inglês | MEDLINE | ID: mdl-37130040

14.

Relationships between Isomeric Metabolism and Regioselective Toxicity of Hydroxychrysenes in Embryos of Japanese Medaka (Oryzias latipes).

Tanabe, Philip; Pampanin, Daniela M; Tiruye, Hiwot M; Jørgensen, Kåre B; Hammond, Rachel I; Gadepalli, Rama S; Rimoldi, John M; Schlenk, Daniel.

Environ Sci Technol ; 57(1): 539-548, 2023 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-36573895

15.

CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin.

Tashiro, Jiro; Sugiura, Akihiro; Warita, Tomoko; Irie, Nanami; Dwi Cahyadi, Danang; Ishikawa, Takuro; Warita, Katsuhiko.

J Pharmacol Sci ; 153(3): 104-112, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37770151

16.

Mechanism-based inactivation of cytochrome P450 3A by evodol.

Zhao, Jie; He, Jingyu; Xu, Jie.

Xenobiotica ; 53(3): 129-139, 2023 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-37092795

17.

Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole.

Kugathas, Indusha; Johansson, Hanna K L; Chan Sock Peng, Edith; Toupin, Maryne; Evrard, Bertrand; Darde, Thomas A; Boberg, Julie; Draskau, Monica K; Rolland, Antoine D; Mazaud-Guittot, Séverine; Chalmel, Frédéric; Svingen, Terje.

Arch Toxicol ; 97(3): 849-863, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36653537

18.

In Vitro Combination of Terbinafine with Ketoconazole Against Aspergillus Species with Terbinafine High MIC Values Isolated From Otomycosis.

Nosratabadi, Mohsen; Espahbodi, Amirreza; Hedayati, Mohammad Taghi; Shokohi, Tahereh; Badali, Hamid; Saeedi, Majid; Moazeni, Maryam; Aghili, Seyed Reza; Javidnia, Javad; Faeli, Leila; Khojasteh, Shaghayegh; Roohi, Behrad; Abbasi, Kiana; Abastabar, Mahdi; Haghani, Iman.

Mycopathologia ; 188(1-2): 119-127, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36449121

19.

ERG11 Gene Variability and Azole Susceptibility in Malassezia pachydermatis.

Díaz, Leyna; Castellá, Gemma; Bragulat, M Rosa; Cabañes, F Javier.

Mycopathologia ; 188(1-2): 21-34, 2023 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-36495417

20.

Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial.

Rousel, Jannik; Saghari, Mahdi; Pagan, Lisa; Nadaban, Andreea; Gambrah, Tom; Theelen, Bart; de Kam, Marieke L; Haakman, Jorine; van der Wall, Hein E C; Feiss, Gary L; Niemeyer-van der Kolk, Tessa; Burggraaf, Jacobus; Bouwstra, Joke A; Rissmann, Robert; van Doorn, Martijn B A.

Int J Mol Sci ; 24(18)2023 Sep 20.

Artigo em Inglês | MEDLINE | ID: mdl-37762625

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Instituto Evandro Chagas

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